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KRE29 Smc5-Smc6 complex subunit KRE29 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856760, updated on 6-Jul-2026
Official Symbol
KRE29
Official Full Name
Smc5-Smc6 complex subunit KRE29
Primary source
SGD:S000000840
Locus tag
YER038C
See related
AllianceGenome:SGD:S000000840; FungiDB:YER038C; VEuPathDB:YER038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NSE6
Summary
Enables ATPase inhibitor activity. Contributes to SUMO transferase activity. Involved in DNA repair. Located in cytoplasm and nucleus. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See KRE29 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (226858..228252, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette family ATPase ARB1 Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase Neighboring gene Fmp49p Neighboring gene putative GDP-mannose transporter Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex. Hallett ST, et al. Nucleic Acids Res, 2021 May 7. PMID 33849072, Free PMC Article
  2. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Yu Y, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35648833, Free PMC Article
  3. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. Taschner M, et al. EMBO J, 2021 Aug 2. PMID 34191293, Free PMC Article
  4. Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Li S, et al. Proc Natl Acad Sci U S A, 2023 Nov 7. PMID 37903273, Free PMC Article
  5. Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Li Q, et al. Nat Struct Mol Biol, 2024 Oct. PMID 38890552, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
  2. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin looping NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair via homologous recombination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of telomere maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Smc5-Smc6 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Smc5-Smc6 complex subunit KRE29
NP_010955.3
  • Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    226858..228252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178929.3 → NP_010955.3  Smc5-Smc6 complex subunit KRE29

    See identical proteins and their annotated locations for NP_010955.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLT7, P40026
    UniProtKB/TrEMBL
    B3LS50
    Conserved Domains (1) summary
    pfam08691
    Location:1 → 454
    Nse5; DNA repair proteins Nse5 and Nse6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40026.1

Gene LinkOut

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