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ARB1 ATP-binding cassette family ATPase ARB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856758, updated on 18-Jan-2023

Summary

Gene symbol
ARB1
Gene description
ATP-binding cassette family ATPase ARB1
Primary source
SGD:S000000838
Locus tag
YER036C
See related
AllianceGenome:SGD:S000000838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP hydrolysis activity. Involved in ribosomal small subunit export from nucleus. Acts upstream of or within protein unfolding. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ARB1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (223367..225199, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Edc2p Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase Neighboring gene Smc5-Smc6 complex subunit KRE29

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ARB1 gene: The ARB1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein unfolding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-binding cassette family ATPase ARB1
NP_010953.1
  • ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    223367..225199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178927.1NP_010953.1  TPA: ATP-binding cassette family ATPase ARB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010953.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLT5, P40024
    UniProtKB/TrEMBL
    A0A0L8VRU4, A0A6A5PWE0, A0A6C1DQ23, A6ZQY5, B3LS48, B5VHH1, G2WCR9, N1P4S7
    Conserved Domains (1) summary
    COG0488
    Location:79601
    Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]