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GCD11 translation initiation factor eIF2 subunit gamma [ Saccharomyces cerevisiae S288C ]

Gene ID: 856746, updated on 18-Sep-2024

Summary

Official Symbol
GCD11
Official Full Name
translation initiation factor eIF2 subunit gamma
Primary source
SGD:S000000827
Locus tag
YER025W
See related
AllianceGenome:SGD:S000000827; FungiDB:YER025W; VEuPathDB:YER025W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SUI4
Summary
Enables translation initiation factor activity and translation initiation factor binding activity. Contributes to GTP binding activity and methionyl-initiator methionine tRNA binding activity. Involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Located in cytosol. Part of several cellular components, including eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and eukaryotic translation initiation factor 2 complex. Used to study MEHMO syndrome and leukodystrophy. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See GCD11 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (205251..206834)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene carnitine O-acetyltransferase YAT2 Neighboring gene tRNA-His Neighboring gene CDP-diacylglycerol-serine O-phosphatidyltransferase

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to methionyl-initiator methionine tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to tRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
enables translation initiation factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables translation initiation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translational fidelity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 43S preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic 48S preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 2 complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of multi-eIF complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translation initiation factor eIF2 subunit gamma
NP_010942.1
  • Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    205251..206834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178916.1NP_010942.1  TPA: translation initiation factor eIF2 subunit gamma [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010942.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS4, P32481
    UniProtKB/TrEMBL
    A6ZQX4, B3LS38, B5VHF9, C7GTD7, C8Z727, G2WCQ8, N1PA85
    Conserved Domains (1) summary
    PTZ00327
    Location:74524
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional