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SRB4 Srb4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856743, updated on 8-Apr-2026
Official Symbol
SRB4
Official Full Name
Srb4p
Primary source
SGD:S000000824
Locus tag
YER022W
See related
AllianceGenome:SGD:S000000824; FungiDB:YER022W; VEuPathDB:YER022W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED17
Summary
Enables DNA-binding transcription factor binding activity; RNA polymerase II complex recruiting activity; and RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to heat; and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Used to study infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SRB4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (198812..200875)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene guanine nucleotide-binding protein subunit alpha Neighboring gene proteasome regulatory particle lid subunit RPN3 Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene carnitine O-acetyltransferase YAT2

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mediator complex association with constitutively transcribed genes in yeast. Ansari SA, et al. Proc Natl Acad Sci U S A, 2009 Sep 29. PMID 19805365, Free PMC Article
  2. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo. Lee D, et al. Nature, 1998 May 28. PMID 9620805
  3. Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex. Kaufmann R, et al. Am J Hum Genet, 2010 Nov 12. PMID 20950787, Free PMC Article
  4. Direct interaction of RNA polymerase II and mediator required for transcription in vivo. Soutourina J, et al. Science, 2011 Mar 18. PMID 21415355
  5. Contact with a component of the polymerase II holoenzyme suffices for gene activation. Barberis A, et al. Cell, 1995 May 5. PMID 7736588

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae.
    Title: Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae.
  2. Data show that Med17(Srb4) are direct targets of mediator histone H4 tail interactions.
    Title: Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions.
  3. identifed direct physical interaction between the Rpb3 Pol II subunit and the Mediator subunit, Med17; findings suggest a direct interaction between Mediator and Pol II is generally required for transcription of class II genes in eukaryotes
    Title: Direct interaction of RNA polymerase II and mediator required for transcription in vivo.
  4. identified as a general transcription factor, comparable in importance to RNA polymerase II and other general factors for the initiation of transcription
    Title: Mediator as a general transcription factor.
  5. characterize Mediator from cells carrying the srb4-138 allele and find that the Mediator complex consistently breaks apart at the head/middle domain boundary even at lower temperatures
    Title: The classical srb4-138 mutant allele causes dissociation of yeast Mediator.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Srb4p
NP_010939.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    198812..200875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178913.1 → NP_010939.1  Srb4p

    See identical proteins and their annotated locations for NP_010939.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS1, P32569, Q06790, Q6B1B4
    UniProtKB/TrEMBL
    A0ABF7PIZ1, A6ZQX1, G2WCQ5
    Conserved Domains (1) summary
    pfam10156
    Location:86 → 569
    Med17; Subunit 17 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32569.1

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