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bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856728, updated on 12-Aug-2025
Official Full Name
bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase
Primary source
SGD:S000000812
Locus tag
YER010C
See related
AllianceGenome:SGD:S000000812; FungiDB:YER010C; VEuPathDB:YER010C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity and oxaloacetate decarboxylase activity. Involved in 3,4-dihydroxybenzoate catabolic process. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (172634..173338, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GTP-Rho binding exocyst subunit SEC3 Neighboring gene Ran GTPase-binding protein NTF2 Neighboring gene GPI-anchored mannoprotein Neighboring gene tRNA-Glu

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of yeast YER010Cp, a knotable member of the RraA protein family. Leulliot N, et al. Protein Sci, 2005 Oct. PMID 16195557, Free PMC Article
  2. Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins. Hanzén S, et al. Cell, 2016 Jun 30. PMID 27264606
  3. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article
  4. Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae. Kyriakou D, et al. BMC Biol, 2016 Dec 7. PMID 27927215, Free PMC Article
  5. Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases. Mazurkewich S, et al. Biochemistry, 2014 Jan 28. PMID 24359411

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxaloacetate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxaloacetate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3,4-dihydroxybenzoate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Preferred Names
bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase
NP_010926.3
  • Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    172634..173338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178901.3 → NP_010926.3  TPA: bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase

    See identical proteins and their annotated locations for NP_010926.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLQ7, P40011
    UniProtKB/TrEMBL
    A0A0L8VSM5, B3LS22, B5VHE0, C8Z710, G2WCP1, N1P3X5
    Conserved Domains (1) summary
    COG0684
    Location:2 → 231
    RraA; Regulator of RNase E activity RraA [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40011.1

Gene LinkOut

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