TMA20 translation machinery-associated protein 20 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TMA20
Official Full Name: translation machinery-associated protein 20
Primary source: SGD:S000002957
Locus tag: YER007C-A
See related: AllianceGenome:SGD:S000002957; FungiDB:YER007C-A; VEuPathDB:YER007C-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable RNA binding activity. Involved in ribosome biogenesis. Acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in cytosol. Human ortholog(s) of this gene implicated in immunodeficiency 118. Orthologous to several human genes including MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.
Title: Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.
40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
Title: 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_010923.3

Ribosome-associated protein; involved along with heterodimeric partner Tma22p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; null mutant exhibits translation defects; localizes to the cytosol; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain