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NUG1 RNA-binding GTPase NUG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856723, updated on 18-Jan-2023

Summary

Gene symbol
NUG1
Gene description
RNA-binding GTPase NUG1
Primary source
SGD:S000000808
Locus tag
YER006W
See related
AllianceGenome:SGD:S000000808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity and RNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal large subunit export from nucleus. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to several human genes including GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See NUG1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (162723..164285)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Fmp52p Neighboring gene apyrase Neighboring gene Pac2p Neighboring gene translation machinery-associated protein 20

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding HDA PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
RNA-binding GTPase NUG1
NP_010921.1
  • GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    162723..164285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178897.1NP_010921.1  TPA: RNA-binding GTPase NUG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010921.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLQ2, P40010
    UniProtKB/TrEMBL
    A0A8H8ULL7, N1P5F6
    Conserved Domains (2) summary
    COG1161
    Location:162481
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:1588
    GN3L_Grn1; GNL3L/Grn1 putative GTPase