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GLC3 1,4-alpha-glucan branching enzyme [ Saccharomyces cerevisiae S288C ]

Gene ID: 856705, updated on 30-Jun-2022

Summary

Gene symbol
GLC3
Gene description
1,4-alpha-glucan branching enzyme
Primary source
SGD:S000000737
Locus tag
YEL011W
See related
AllianceGenome:SGD:S000000737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GHA1
Summary
Enables 1,4-alpha-glucan branching enzyme activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Used to study glycogen storage disease IV. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See GLC3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (133120..135234)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene E2 ubiquitin-conjugating protein UBC8 Neighboring gene tRNA-Lys Neighboring gene uncharacterized protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the GLC3 gene: The GLC3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 1,4-alpha-glucan branching enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1,4-alpha-glucan branching enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables 1,4-alpha-glucan branching enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cation binding IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
1,4-alpha-glucan branching enzyme
NP_010905.1
  • Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    133120..135234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178826.1NP_010905.1  TPA: 1,4-alpha-glucan branching enzyme [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010905.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32775
    Conserved Domains (1) summary
    PLN02447
    Location:9702
    PLN02447; 1,4-alpha-glucan-branching enzyme