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PMP2 proteolipid ATPase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856697, updated on 8-Mar-2025

Summary

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Official Symbol
PMP2
Official Full Name
proteolipid ATPase
Primary source
SGD:S000002103
Locus tag
YEL017C-A
See related
AllianceGenome:SGD:S000002103; FungiDB:YEL017C-A; VEuPathDB:YEL017C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Involved in positive regulation of ATP-dependent activity. Located in membrane. Is active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
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Genomic context

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See PMP2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (122798..122929, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene SUMO ligase MMS21 Neighboring gene Eaf5p Neighboring gene Gtt3p Neighboring gene nucleotide diphosphatase/phosphodiesterase NPP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plasma membrane H(+)-ATPase of Saccharomyces cerevisiae is regulated by two small 38-residue isoproteolipids. Navarre C, et al. Folia Microbiol (Praha), 1998. PMID 9721615
  2. Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. Navarre C, et al. J Biol Chem, 1994 Aug 19. PMID 8063750
  3. A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Michelsen K, et al. Traffic, 2006 Jul. PMID 16734667
  4. Divergent RNA binding specificity of yeast Puf2p. Yosefzon Y, et al. RNA, 2011 Aug. PMID 21685478, Free PMC Article
  5. Global identification of new substrates for the yeast endoribonuclease, RNase mitochondrial RNA processing (MRP). Aulds J, et al. J Biol Chem, 2012 Oct 26. PMID 22977255, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role of 14-3-3 in the trafficking of this multimeric Pmp2p reporter is isoform-specific
    Title: A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of ATP-dependent activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
proteolipid ATPase
NP_010898.1
  • Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    122798..122929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180029.1 → NP_010898.1  TPA: proteolipid ATPase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010898.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLN2, P40975
    UniProtKB/TrEMBL
    A6ZQT2, B3LRZ9, C7GX26, C8Z6Y2, G2WCL5, N1P5M1
    Conserved Domains (1) summary
    pfam08114
    Location:1 → 43
    PMP1_2; ATPase proteolipid family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40975.1

Gene LinkOut

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