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URA3 orotidine-5'-phosphate decarboxylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856692, updated on 14-Aug-2021

Summary

Gene symbol
URA3
Gene description
orotidine-5'-phosphate decarboxylase
Primary source
SGD:S000000747
Locus tag
YEL021W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See URA3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (116167..116970)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Arf family guanine nucleotide exchange factor GEA2 Neighboring gene protein transporter TIM9 Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the URA3 gene: The URA3 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables orotidine-5'-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables orotidine-5'-phosphate decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables orotidine-5'-phosphate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables orotidine-5'-phosphate decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
orotidine-5'-phosphate decarboxylase
NP_010893.3
  • Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    116167..116970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178836.3NP_010893.3  TPA: orotidine-5'-phosphate decarboxylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010893.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03962
    Conserved Domains (1) summary
    cl21457
    Location:32252
    TIM; TIM-like beta/alpha barrel domains
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