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GDA1 guanosine diphosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856669, updated on 10-May-2026
Official Symbol
GDA1
Official Full Name
guanosine diphosphatase
Primary source
SGD:S000000768
Locus tag
YEL042W
See related
AllianceGenome:SGD:S000000768; FungiDB:YEL042W; VEuPathDB:YEL042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GDP phosphatase activity and UDP phosphatase activity. Involved in protein glycosylation. Located in Golgi apparatus. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)) and ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (73771..75327)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ies6p Neighboring gene Gta1p Neighboring gene NADH/NAD(+) kinase Neighboring gene chitin transglycosylase UTR2

Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A guanosine diphosphatase enriched in Golgi vesicles of Saccharomyces cerevisiae. Purification and characterization. Yanagisawa K, et al. J Biol Chem, 1990 Nov 5. PMID 2172253
  2. The Golgi guanosine diphosphatase is required for transport of GDP-mannose into the lumen of Saccharomyces cerevisiae Golgi vesicles. Berninsone P, et al. J Biol Chem, 1994 Jan 7. PMID 7506254
  3. Regulation of yeast Golgi glycosylation. Guanosine diphosphatase functions as a homodimer in the membrane. Berninsone P, et al. J Biol Chem, 1995 Jun 16. PMID 7540172
  4. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. Abeijon C, et al. J Cell Biol, 1993 Jul. PMID 8391537, Free PMC Article
  5. A role for the lumenal domain in Golgi localization of the Saccharomyces cerevisiae guanosine diphosphatase. Vowels JJ, et al. Mol Biol Cell, 1998 Jun. PMID 9614179, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
guanosine diphosphatase
NP_010872.1
  • Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    73771..75327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178857.1 → NP_010872.1  guanosine diphosphatase

    See identical proteins and their annotated locations for NP_010872.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLK7, P32621
    UniProtKB/TrEMBL
    A6ZQQ8, B3LRX4, B5VH93, C7GKE5, C8Z6V2, G2WCJ1, N1P5J2
    Conserved Domains (1) summary
    COG5371
    Location:1 → 518
    COG5371; Golgi nucleoside diphosphatase [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32621.1

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