Format

Send to:

Choose Destination

NPR2 nitrogen permease regulating protein NPR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856647, updated on 22-Aug-2021

Summary

Gene symbol
NPR2
Gene description
nitrogen permease regulating protein NPR2
Primary source
SGD:S000000788
Locus tag
YEL062W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NPR2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (34407..36254)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Avt2p Neighboring gene arginine permease CAN1 Neighboring gene kinesin motor protein CIN8 Neighboring gene proteinase B

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the NPR2 gene: The NPR2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proline transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urea transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of GATOR1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Seh1-associated complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extrinsic component of fungal-type vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of fungal-type vacuolar membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nitrogen permease regulating protein NPR2
NP_010852.4
  • Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    34407..36254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178877.3NP_010852.4  TPA: nitrogen permease regulating protein NPR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010852.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39923
    Conserved Domains (1) summary
    cl24021
    Location:9490
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
Support Center