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SCH9 serine/threonine protein kinase SCH9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856612, updated on 7-Oct-2018

Summary

Gene symbol
SCH9
Gene description
serine/threonine protein kinase SCH9
Primary source
SGD:S000001248
Locus tag
YHR205W
Gene type
protein coding
RNA name
serine/threonine protein kinase SCH9
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRM2; KOM1

Genomic context

See SCH9 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (509363..511837)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S4B Neighboring gene alpha-1,2-mannosidase MNL1 Neighboring gene kinase-regulated stress-responsive transcription factor SKN7 Neighboring gene S-adenosylmethionine-dependent methyltransferase

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SCH9 gene: The SCH9 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, K.lactis, and E.gossypii.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
age-dependent response to oxidative stress involved in chronological cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase I IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size HMP PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
fungal-type vacuole membrane HDA PubMed 
fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine protein kinase SCH9
NP_012075.1
  • AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    509363..511837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179336.1NP_012075.1  TPA: serine/threonine protein kinase SCH9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012075.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11792
    Conserved Domains (3) summary
    cd11651
    Location:181407
    YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1
    smart00220
    Location:412671
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05586
    Location:418738
    STKc_Sck1_like; Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases
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