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SCH9 serine/threonine protein kinase SCH9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856612, updated on 18-Jan-2023

Summary

Gene symbol
SCH9
Gene description
serine/threonine protein kinase SCH9
Primary source
SGD:S000001248
Locus tag
YHR205W
See related
AllianceGenome:SGD:S000001248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRM2; KOM1
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including regulation of cellular biosynthetic process; regulation of cysteine metabolic process; and regulation of response to osmotic stress. Located in fungal-type vacuole membrane and nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); colorectal cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including SGK1 (serum/glucocorticoid regulated kinase 1) and SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SCH9 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (509363..511837)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S4B Neighboring gene alpha-1,2-mannosidase MNL1 Neighboring gene kinase-regulated stress-responsive transcription factor SKN7 Neighboring gene S-adenosylmethionine-dependent methyltransferase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hydrogen sulfide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell size HMP PubMed 
involved_in regulation of cysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
serine/threonine protein kinase SCH9
NP_012075.1
  • AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    509363..511837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179336.1NP_012075.1  TPA: serine/threonine protein kinase SCH9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012075.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLF4, P11792
    UniProtKB/TrEMBL
    A0A8H4F9Z5, B3LSW6, N1P1D0
    Conserved Domains (2) summary
    cd11651
    Location:181407
    YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1
    cd05586
    Location:418738
    STKc_Sck1_like; Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases