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AIM18 Aim18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856605, updated on 24-Jan-2026
Official Symbol
AIM18
Official Full Name
Aim18p
Primary source
SGD:S000001241
Locus tag
YHR198C
See related
AllianceGenome:SGD:S000001241; FungiDB:YHR198C; VEuPathDB:YHR198C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FMP22
Summary
Enables heme binding activity. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See AIM18 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (496315..497280, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Utp9p Neighboring gene Rix1p Neighboring gene Aim46p Neighboring gene borealin

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae. Schmitz JM, et al. J Biol Chem, 2023 Mar. PMID 36739946, Free PMC Article
  2. Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling. Stefely JA, et al. Nat Biotechnol, 2016 Nov. PMID 27669165, Free PMC Article
  3. Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress. Jaworek W, et al. J Biol Chem, 2022 Oct. PMID 36115461, Free PMC Article
  4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229
  5. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
    Title: Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables intramolecular lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Aim18p
NP_012068.1
  • Hemoprotein; hypothetical protein that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    496315..497280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179329.1 → NP_012068.1  Aim18p

    See identical proteins and their annotated locations for NP_012068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZTA4, B3LSV8, B5VKC6, C8Z9Z8, D3DLE6, P38884
    UniProtKB/TrEMBL
    G2WFS1, N1P9I7
    Conserved Domains (1) summary
    pfam16035
    Location:113 → 311
    Chalcone_2; Chalcone isomerase like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38884.1

Gene LinkOut

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