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OYE2 NADPH dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856584, updated on 18-Jan-2023

Summary

Gene symbol
OYE2
Gene description
NADPH dehydrogenase
Primary source
SGD:S000001222
Locus tag
YHR179W
See related
AllianceGenome:SGD:S000001222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NADPH dehydrogenase activity. Involved in apoptotic process. Located in cytoplasm and nucleus. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See OYE2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (462502..463704)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rof1p Neighboring gene Stb5p Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 
enables NADPH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADPH dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NADPH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables pentaerythritol trinitrate reductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADPH dehydrogenase
NP_012049.1
  • Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    462502..463704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179310.1NP_012049.1  TPA: NADPH dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P8V8, Q03558
    UniProtKB/TrEMBL
    A0A8H4C0Z5, N1P1A6
    Conserved Domains (1) summary
    cd02933
    Location:16372
    OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...