STB5 Stb5p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STB5
Official Full Name: Stb5p
Primary source: SGD:S000001221
Locus tag: YHR178W
See related: AllianceGenome:SGD:S000001221; FungiDB:YHR178W; VEuPathDB:YHR178W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity. Involved in cellular response to oxidative stress; regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STB5 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (459299..461530)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.
Title: The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.
Comparison between instrumental variable and mediation-based methods for reconstructing causal gene networks in yeast.
Title: Comparison between instrumental variable and mediation-based methods for reconstructing causal gene networks in yeast.
Transcriptome analysis of an STB5 deletion strain revealed transcriptional changes in direct regulation targets of Stb5, including several pentose phosphate pathway genes as well as additional novel regulatory targets, but interestingly not including the proposed pentose phosphate pathway flux controlling enzyme Zwf1.
Title: Integrated analysis of the yeast NADPH-regulator Stb5 reveals distinct differences in NADPH requirements and regulation in different states of yeast metabolism.
These findings suggest a major role for the transcription factor Stb5p in maintaining a basal flux through the pentose phosphate pathway to meet the NADPH requirements for aerobic growth, and to provide the nucleotide precursors.
Title: The Saccharomyces cerevisiae zinc factor protein Stb5p is required as a basal regulator of the pentose phosphate pathway.
Stb5p functions as a transcriptionalr egulator controlling expression of the PPP genes and glucose-6-phosphate isomerase, which leads to acetaldehyde tolerance.
Title: Transcription factor Stb5p is essential for acetaldehyde tolerance in Saccharomyces cerevisiae.
YMR315W transcription is regulated by Stb5p in response to diamide induced NADPH depletion.
Title: The Saccharomyces cerevisiae YMR315W gene encodes an NADP(H)-specific oxidoreductase regulated by the transcription factor Stb5p in response to NADPH limitation.
These data suggest that Stb5 is a key player in the control of NADPH production for resistance to oxidative stress.
Title: Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Stb5p

NP_012048.3

Transcription factor; regulates multidrug resistance and the oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; negative regulator of autophagy, modulating the transcription of genes involved in NADPH production and the pentose phosphate pathway; Stb5p expression is reduced during nitrogen starvation and autophagy induction, while STB5 mRNA levels are significantly increased

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

459299..461530

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179309.3 → NP_012048.3 TPA: Stb5p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012048.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLC7, P38699

UniProtKB/TrEMBL

A6ZT85, C7GW81, G2WFQ2, N1P2H2

Conserved Domains (2) summary

cd12148
Location:293 → 699

fungal_TF_MHR; fungal transcription factor regulatory middle homology region

pfam00172
Location:20 → 58

Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain