SPC97 Spc97p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SPC97
Official Full Name: Spc97p
Primary source: SGD:S000001215
Locus tag: YHR172W
See related: AllianceGenome:SGD:S000001215; FungiDB:YHR172W; VEuPathDB:YHR172W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables gamma-tubulin binding activity. Involved in cytoplasmic microtubule organization and microtubule nucleation. Located in inner plaque of spindle pole body and outer plaque of spindle pole body. Part of gamma-tubulin small complex. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-tubulin complex	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin small complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin small complex	IPI Inferred from Physical Interaction more info	PubMed
located_in inner plaque of spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle pole body	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in outer plaque of spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	HDA more info	PubMed
located_in spindle pole body	IEA Inferred from Electronic Annotation more info

NP_012042.1

Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

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The following sections contain reference sequences that belong to a specific genome build. Explain