CDC23 anaphase promoting complex subunit CDC23 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC23
Gene description: anaphase promoting complex subunit CDC23
Primary source: SGD:S000001209
Locus tag: YHR166C
See related: AllianceGenome:SGD:S000001209
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cyclin binding activity. Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and protein ubiquitination. Part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CDC23 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (437170..439050, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S phase chromatin association of DNA polymerase alpha-primase and the GINS complex is affected by Cdc23 inactivation. An important function of Cdc23 in DNA replication may be to assist in the docking of DNA polymerase alpha-primase to chromatin.
Title: Nuclear distribution and chromatin association of DNA polymerase alpha-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the CDC23 gene: The CDC23 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anaphase promoting complex subunit CDC23

NP_012036.1

Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

437170..439050 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179297.1 → NP_012036.1 TPA: anaphase promoting complex subunit CDC23 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012036.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLB5, P16522

UniProtKB/TrEMBL

A0A0L8VPJ7, A0A6A5PYL8, A0A6C1DSK9, A6ZT74, B3LST0, B5VK93, C8Z9W4, G2WFP0, N1P4U4

Conserved Domains (3) summary

COG0457
Location:307 → 561

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:433 → 459

TPR; TPR repeat [structural motif]

pfam04049
Location:12 → 144

ANAPC8; Anaphase promoting complex subunit 8 / Cdc23