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RPC10 DNA-directed RNA polymerase core subunit RPC10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856547, updated on 10-Feb-2026
Official Symbol
RPC10
Official Full Name
DNA-directed RNA polymerase core subunit RPC10
Primary source
SGD:S000001185
Locus tag
YHR143W-A
See related
AllianceGenome:SGD:S000001185; FungiDB:YHR143W-A; VEuPathDB:YHR143W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPB12
Summary
Enables zinc ion binding activity. Contributes to DNA-directed RNA polymerase activity and RNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Located in peroxisome. Part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RPC10 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (387233..387445)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Chs7p Neighboring gene Dse2p Neighboring gene deoxycytidine monophosphate deaminase Neighboring gene tRNA-Pro

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. RPC10 encodes a new mini subunit shared by yeast nuclear RNA polymerases. Treich I, et al. Gene Expr, 1992. PMID 1617300, Free PMC Article
  2. ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels. Levi O, et al. Genes (Basel), 2023 Feb 10. PMID 36833389, Free PMC Article
  3. Two additional common subunits, ABC10 alpha and ABC10 beta, are shared by yeast RNA polymerases. Carles C, et al. J Biol Chem, 1991 Dec 15. PMID 1748681
  4. Molecular Structures of Transcribing RNA Polymerase I. Tafur L, et al. Mol Cell, 2016 Dec 15. PMID 27867008, Free PMC Article
  5. [Molecular cloning and characterization of cDNA of the rpc10+ gene encoding the smallest subunit of nuclear RNA polymerases of Schizosaccharomyces pombe]. Shpakovskiĭ GV, et al. Bioorg Khim, 1997 May. PMID 9290054

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels.
    Title: ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels.
  2. Molecular structure of transcribing RNA polymerase I has been presented.
    Title: Molecular Structures of Transcribing RNA Polymerase I.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in termination of RNA polymerase I transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in termination of RNA polymerase III transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase I promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase III promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleolus HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-directed RNA polymerase core subunit RPC10
NP_012013.1
  • RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress; localizes to the peroxisome in a Pex5p-dependent manner

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    387233..387445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179273.1 → NP_012013.1  DNA-directed RNA polymerase core subunit RPC10

    See identical proteins and their annotated locations for NP_012013.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL93, P40422
    UniProtKB/TrEMBL
    A0ABF7PIV9, A6ZT52, B3LSQ8, C7GXW4, C8Z9U1, G2WFL7, N1P4S0
    Conserved Domains (1) summary
    smart00659
    Location:27 → 70
    RPOLCX; RNA polymerase subunit CX
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40422.1

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