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EPT1 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856523, updated on 17-May-2024

Summary

Gene symbol
EPT1
Gene description
bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
Primary source
FungiDB:YHR123W
Locus tag
YHR123W
See related
SGD:S000001165; AllianceGenome:SGD:S000001165; VEuPathDB:YHR123W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Involved in phosphatidylcholine biosynthetic process and phosphatidylethanolamine biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to several human genes including SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See EPT1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (354815..356081)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Lsm12p Neighboring gene iron-sulfur cluster assembly protein CIA2 Neighboring gene transcription factor NDT80 Neighboring gene tRNA-Phe

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
NP_011991.1
  • sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    354815..356081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179253.1NP_011991.1  TPA: bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011991.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL73, P22140
    UniProtKB/TrEMBL
    B3LSN8, C8Z9R6, N1P9F5
    Conserved Domains (1) summary
    COG5050
    Location:2391
    EPT1; sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid metabolism]