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LSM12 Lsm12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856521, updated on 18-Sep-2024

Summary

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Official Symbol
LSM12
Official Full Name
Lsm12p
Primary source
SGD:S000001163
Locus tag
YHR121W
See related
AllianceGenome:SGD:S000001163; FungiDB:YHR121W; VEuPathDB:YHR121W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in RNA metabolic process. Located in cytoplasmic stress granule. Orthologous to human LSM12 (LSM12 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LSM12 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (352756..353319)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone methyltransferase SET1 Neighboring gene mismatch repair ATPase MSH1 Neighboring gene iron-sulfur cluster assembly protein CIA2 Neighboring gene bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nst1, Densely Associated to P-Body in the Post-Exponential Phases of Saccharomyces cerevisiae, Shows an Intrinsic Potential of Producing Liquid-Like Condensates of P-Body Components in Cells. Choi YJ, et al. Int J Mol Sci, 2022 Feb 24. PMID 35269643, Free PMC Article
  2. The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. Yang S, et al. BMC Microbiol, 2010 May 7. PMID 20459639, Free PMC Article
  3. Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. Swisher KD, et al. PLoS One, 2010 Apr 2. PMID 20368989, Free PMC Article
  4. Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats. Ostrowski LA, et al. Commun Biol, 2018. PMID 30417124, Free PMC Article
  5. Lsm12 Mediates Deubiquitination of DNA Polymerase η To Help Saccharomyces cerevisiae Resist Oxidative Stress. Yao R, et al. Appl Environ Microbiol, 2019 Jan 1. PMID 30366994, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lsm12 is a novel regulator mediating Poleta deubiquitination that regulates its recruitment in response to DNA damage induced by oxidative stress.
    Title: Lsm12 Mediates Deubiquitination of DNA Polymerase η To Help Saccharomyces cerevisiae Resist Oxidative Stress.
  2. Pbp4 and Lsm12 proteins did not dramatically affect the formation of stress granules or P-bodies.
    Title: Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA metabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in RNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lsm12p
NP_011989.1
  • hypothetical protein that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    352756..353319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179251.1 → NP_011989.1  TPA: Lsm12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011989.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL71, P38828
    UniProtKB/TrEMBL
    A6ZT29, B3LSN6, B5VK56, C7GR67, C8Z9R4, G2WFJ5, N1P299
    Conserved Domains (1) summary
    smart00995
    Location:80 → 170
    AD; Anticodon-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38828.1

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