ORC6 origin recognition complex subunit 6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ORC6
Gene description: origin recognition complex subunit 6
Primary source: SGD:S000001160
Locus tag: YHR118C
Gene type: protein coding
RNA name: origin recognition complex subunit 6
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

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See ORC6 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (344321..345628, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

The Orc6 RXL/cyclin-binding motif plays a positive role in the initial recruitment of Cdt1/Mcm2-7 to the origin, suggesting that this motif is critical for the switch between active and inhibited ORC function at the G1-to-S-phase transition.
Title: CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.
In this study, yeast two-hybrid analysis was used to examine the interaction between Cdt1p and every ORC subunit; potent interaction with Orc6p, and weaker interaction with Orc2p and Orc5p was observed.
Title: Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
Orc6 is required for dynamic recruitment of Cdt1 during repeated loading of DNA helicases.
Title: Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
Orc6 was required for entry into S phase after pre-replicative complexes formation
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
The 'hydrophobic patch' (HP) of the Saccharomyces cerevisiae S-phase cyclin Clb5 facilitates its interaction with Orc6 (via its Cy or RXL motif), providing a mechanism that helps prevent rereplication from individual origins.
Title: Two-faced cyclins with eyes on the targets.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell cycle - yeast, organism-specific biosystem (from KEGG)
Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
Cell cycle - yeast, conserved biosystem (from KEGG)
Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
Meiosis - yeast, organism-specific biosystem (from KEGG)
Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Meiosis - yeast, conserved biosystem (from KEGG)
Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Origin recognition complex, organism-specific biosystem (from KEGG)
Origin recognition complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
Origin recognition complex, conserved biosystem (from KEGG)
Origin recognition complex, conserved biosystemStructural complex; Genetic information processing; Replication system

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the ORC6 gene: The ORC6 gene is conserved in S.cerevisiae, K.lactis, and E.gossypii.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
chromatin silencing at silent mating-type cassette	IDA Inferred from Direct Assay more info	PubMed
pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
DNA replication preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info
nuclear origin of replication recognition complex	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: origin recognition complex subunit 6

NP_011986.1

Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

344321..345628 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179248.1 → NP_011986.1 TPA: origin recognition complex subunit 6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011986.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P38826

Conserved Domains (1) summary

pfam05460
Location:22 → 416

ORC6; Origin recognition complex subunit 6 (ORC6)