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KSP1 putative serine/threonine protein kinase KSP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856482, updated on 12-Aug-2025
Official Symbol
KSP1
Official Full Name
putative serine/threonine protein kinase KSP1
Primary source
SGD:S000001124
Locus tag
YHR082C
See related
AllianceGenome:SGD:S000001124; FungiDB:YHR082C; VEuPathDB:YHR082C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity and protein kinase activity. Involved in several processes, including TOR signaling; negative regulation of macroautophagy; and regulation of pseudohyphal growth. Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See KSP1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (268459..271548, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Lam4p Neighboring gene Lrp1p Neighboring gene SAM complex subunit SAM35 Neighboring gene homeodomain family transcription factor STE12

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Stress-Responsive Signaling Network Regulating Pseudohyphal Growth and Ribonucleoprotein Granule Abundance in Saccharomyces cerevisiae. Mutlu N, et al. Genetics, 2019 Oct. PMID 31455721, Free PMC Article
  2. CTT1 overexpression increases the replicative lifespan of MMS-sensitive Saccharomyces cerevisiae deficient in KSP1. Zhao W, et al. Mech Ageing Dev, 2017 Jun. PMID 28347693
  3. Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Fleischmann M, et al. Mol Gen Genet, 1996 Mar 20. PMID 8676864
  4. Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation. Hanley SE, et al. Mol Biol Cell, 2024 Nov 1. PMID 39320938, Free PMC Article
  5. Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. Umekawa M, et al. J Biol Chem, 2012 May 11. PMID 22447937, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Ksp1p kinase signaling network integrates polarized pseudohyphal morphogenesis and translational regulation through the stress-responsive transcriptional control of pathways for amino acid metabolism and post-translational modification of translation factors affecting stress granule abundance.
    Title: A Stress-Responsive Signaling Network Regulating Pseudohyphal Growth and Ribonucleoprotein Granule Abundance in Saccharomyces cerevisiae.
  2. Results indicate that putative serine/threonine protein kinase KSP1 (Ksp1) directly phosphorylates eukaryotic translation initiation factor 4G (eIF4G).
    Title: Ksp1-dependent phosphorylation of eIF4G modulates post-transcriptional regulation of specific mRNAs under glucose deprivation conditions.
  3. the KSP1 deficiency also leads to a shortened replicative lifespan, which could be restored by the increased expression of CTT1. On the other hand, KSP1-overexpressed (KSP1OX) yeast cells exhibited increased resistance towards MMS, an effect that was, at least in part, CTT1 independent.
    Title: CTT1 overexpression increases the replicative lifespan of MMS-sensitive Saccharomyces cerevisiae deficient in KSP1.
  4. identifies Ksp1 as a new component that functions as part of the PKA and TORC1 signaling network to control the magnitude of autophagy.
    Title: Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in TOR signaling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in intracellular protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative serine/threonine protein kinase KSP1
NP_011950.1
  • Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    268459..271548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179212.1 → NP_011950.1  TPA: putative serine/threonine protein kinase KSP1

    See identical proteins and their annotated locations for NP_011950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL33, P38691
    UniProtKB/TrEMBL
    A0A0L8VPB7, A6ZSZ1, C7GWU5, C8Z9M6, G2WFF6, N1P258
    Conserved Domains (1) summary
    cd13993
    Location:17 → 348
    STKc_Pat1_like; Catalytic domain of Fungal Pat1-like Serine/Threonine kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38691.1

Gene LinkOut

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