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QNS1 glutamine-dependent NAD(+) synthetase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856473, updated on 24-Apr-2022

Summary

Gene symbol
QNS1
Gene description
glutamine-dependent NAD(+) synthetase
Primary source
SGD:S000001116
Locus tag
YHR074W
See related
AllianceGenome:SGD:S000001116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NAD+ synthase (glutamine-hydrolyzing) activity and glutaminase activity. Involved in NAD biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See QNS1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (246193..248337)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene snoRNP complex protein NOP10 Neighboring gene oxysterol-binding protein related protein OSH3 Neighboring gene carboxylesterase-mitochondrial 37S ribosomal protein YmS2 Neighboring gene type 2C protein phosphatase PTC7

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the QNS1 gene: The QNS1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in NAD biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in NAD biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamine-dependent NAD(+) synthetase
NP_011941.1
  • Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    246193..248337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179204.1NP_011941.1  TPA: glutamine-dependent NAD(+) synthetase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011941.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38795
    Conserved Domains (1) summary
    PLN02339
    Location:4704
    PLN02339; NAD+ synthase (glutamine-hydrolysing)