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NOP10 snoRNP complex protein NOP10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856471, updated on 21-Dec-2025
Official Symbol
NOP10
Official Full Name
snoRNP complex protein NOP10
Primary source
SGD:S000007455
Locus tag
YHR072W-A
See related
AllianceGenome:SGD:S000007455; FungiDB:YHR072W-A; VEuPathDB:YHR072W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in rRNA pseudouridine synthesis and snRNA pseudouridine synthesis. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See NOP10 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (241664..241840)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene lanosterol synthase ERG7 Neighboring gene oxysterol-binding protein related protein OSH3 Neighboring gene glutamine-dependent NAD(+) synthetase

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Nop10 is a conserved H/ACA snoRNP molecular adaptor. Reichow SL, et al. Biochemistry, 2008 Jun 10. PMID 18473479
  2. Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA. Khanna M, et al. RNA, 2006 Jan. PMID 16373493, Free PMC Article
  3. Base-pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins. Kelly EK, et al. RNA, 2019 Oct. PMID 31311819, Free PMC Article
  4. Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs. Henras AK, et al. RNA, 2004 Nov. PMID 15388873, Free PMC Article
  5. Increasing the Depth of Mass-Spectrometry-Based Structural Analysis of Protein Complexes through the Use of Multiple Cross-Linkers. Ding YH, et al. Anal Chem, 2016 Apr 19. PMID 27010980

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snoRNA guided rRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box H/ACA snoRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of box H/ACA snoRNP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
snoRNP complex protein NOP10
NP_058135.1
  • Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    241664..241840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184438.1 → NP_058135.1  TPA: snoRNP complex protein NOP10

    See identical proteins and their annotated locations for NP_058135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL22, Q6Q547
    UniProtKB/TrEMBL
    A6ZSX9, B3LSJ0, C7GWT4, C8Z9L3, G2WFE5, N1P2N0
    Conserved Domains (1) summary
    pfam04135
    Location:4 → 52
    Nop10p; Nucleolar RNA-binding protein, Nop10p family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q547.1

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