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DYS1 deoxyhypusine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856465, updated on 23-Apr-2026
Official Symbol
DYS1
Official Full Name
deoxyhypusine synthase
Primary source
SGD:S000001110
Locus tag
YHR068W
See related
AllianceGenome:SGD:S000001110; FungiDB:YHR068W; VEuPathDB:YHR068W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables deoxyhypusine synthase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Located in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See DYS1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (232133..233296)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein Neighboring gene hydroxyacyl-thioester dehydratase HTD2 Neighboring gene exosome non-catalytic core subunit RRP4 Neighboring gene tRNA (guanine) methyltransferase

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme. Kang KR, et al. J Biol Chem, 1995 Aug 4. PMID 7629166
  2. Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae. Sasaki K, et al. FEBS Lett, 1996 Apr 15. PMID 8612813
  3. Novel features of the functional site and expression of the yeast deoxyhypusine synthase. Abid R, et al. Biol Signals, 1997 May-Jun. PMID 9285099
  4. Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation. Wolff EC, et al. Yeast, 1999 Jan 15. PMID 10028184
  5. Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. Thompson GM, et al. FEBS Lett, 2003 Dec 18. PMID 14675757

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables deoxyhypusine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyhypusine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxyhypusine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-hypusine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-hypusine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
deoxyhypusine synthase
NP_011935.1
  • Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    232133..233296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179198.1 → NP_011935.1  deoxyhypusine synthase

    See identical proteins and their annotated locations for NP_011935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL17, P38791
    UniProtKB/TrEMBL
    A6ZSX4, B3LSI6, B5VJZ6, C7GWS9, C8Z9K6, G2WFE0, N1P2M4
    Conserved Domains (1) summary
    pfam01916
    Location:48 → 373
    DS; Deoxyhypusine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38791.1

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