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VMA22 Vma22p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856457, updated on 5-Jul-2025
Official Symbol
VMA22
Official Full Name
Vma22p
Primary source
SGD:S000001102
Locus tag
YHR060W
See related
AllianceGenome:SGD:S000001102; FungiDB:YHR060W; VEuPathDB:YHR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CEV1; VPH6
Summary
Enables unfolded protein binding activity. Involved in vacuolar acidification and vacuolar proton-transporting V-type ATPase complex assembly. Located in nucleus. Part of Vma12-Vma22 assembly complex. Used to study congenital disorder of glycosylation type IIo. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human CCDC115 (coiled-coil domain containing 115). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See VMA22 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (220725..221270)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mediator complex subunit MED6 Neighboring gene mitochondrial 37S ribosomal protein mS41 FYV4 Neighboring gene Gic1p Neighboring gene RNA-binding RNA processing protein RPP1

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genes required for vacuolar acidity in Saccharomyces cerevisiae. Preston RA, et al. Genetics, 1992 Jul. PMID 1628805, Free PMC Article
  2. vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. Hemenway CS, et al. Genetics, 1995 Nov. PMID 8582630, Free PMC Article
  3. Vma22p is a novel endoplasmic reticulum-associated protein required for assembly of the yeast vacuolar H(+)-ATPase complex. Hill KJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673216
  4. Assembly of the yeast vacuolar proton-translocating ATPase. Graham LA, et al. J Bioenerg Biomembr, 1999 Feb. PMID 10340847
  5. Assembly of the yeast vacuolar H+-ATPase occurs in the endoplasmic reticulum and requires a Vma12p/Vma22p assembly complex. Graham LA, et al. J Cell Biol, 1998 Jul 13. PMID 9660861, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Vma12-Vma22 assembly complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Vma12-Vma22 assembly complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus HDA PubMed 
Preferred Names
Vma22p
NP_011927.1
  • Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    220725..221270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179190.1 → NP_011927.1  TPA: Vma22p

    See identical proteins and their annotated locations for NP_011927.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL09, P38784
    UniProtKB/TrEMBL
    A6ZSW6, B3LSH9, B5VJY7, C7GTX3, C8Z9J7, G2WFD2, N1P4I6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38784.1

Gene LinkOut

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