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CUP1-1 metallothionein CUP1-1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856450, updated on 5-Jul-2025
Official Symbol
CUP1-1
Official Full Name
metallothionein CUP1-1
Primary source
SGD:S000001095
Locus tag
YHR053C
See related
AllianceGenome:SGD:S000001095; FungiDB:YHR053C; VEuPathDB:YHR053C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CUP1
Summary
Enables cadmium ion binding activity; copper ion binding activity; and superoxide dismutase activity. Involved in detoxification of cadmium ion; detoxification of copper ion; and removal of superoxide radicals. Located in cytosol. Is active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See CUP1-1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (212535..212720, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VI Neighboring gene Cic1p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1-2

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and expression of Saccharomyces cerevisiae copper-metallothionein gene in Escherichia coli and characterization of the recombinant protein. Sayers Z, et al. Eur J Biochem, 1993 Mar 1. PMID 8444189
  2. Tandem gene amplification mediates copper resistance in yeast. Fogel S, et al. Proc Natl Acad Sci U S A, 1982 Sep. PMID 6291039, Free PMC Article
  3. Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Karin M, et al. Proc Natl Acad Sci U S A, 1984 Jan. PMID 6364141, Free PMC Article
  4. Cloning and expression of a yeast copper metallothionein gene. Butt TR, et al. Gene, 1984 Jan. PMID 6370791
  5. Copper metallothionein of yeast, structure of the gene, and regulation of expression. Butt TR, et al. Proc Natl Acad Sci U S A, 1984 Jun. PMID 6374656, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
    Title: The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
  2. It has been shown that RSC does not affect the nucleosomal occupancy at CUP1. Therefore, transient binding of Ace1p and rapid bursts of transcription at CUP1 may be dependent on short repetitive cycles of nucleosome mobilization.
    Title: Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast.
  3. Data indicate that copy number variation (CNV) is regulated by both promoter activity and acetylation of histone H3 lysine 56 (H3K56ac) and that H3K56ac is required for copper-resistance gene CUP1 CNV and efficient copper adaptation.
    Title: Environmental change drives accelerated adaptation through stimulated copy number variation.
  4. Although interhomolog mitotic recombination in the CUP1 locus is elevated relative to the average genomic region, we found that interhomolog meiotic recombination in the array is reduced compared to most regions
    Title: Properties of Mitotic and Meiotic Recombination in the Tandemly-Repeated CUP1 Gene Cluster in the Yeast Saccharomyces cerevisiae.
  5. The induction of CUP1 requires the presence of Ace1p and the binding of Ace1p at the CUP1 promoter during activation provides evidence that Ace1p is directly involved in CUP1 induction.
    Title: Chromatin repositioning activity and transcription machinery are both recruited by Ace1p in yeast CUP1 activation.
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Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antioxidant activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antioxidant activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables cadmium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadmium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in detoxification of cadmium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in detoxification of cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detoxification of copper ion IEA
Inferred from Electronic Annotation
more info
  
involved_in detoxification of copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in removal of superoxide radicals IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in removal of superoxide radicals IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
metallothionein CUP1-1
NP_011922.1
  • Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    212535..212720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179185.1 → NP_011922.1  TPA: metallothionein CUP1-1

    See identical proteins and their annotated locations for NP_011922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL02, P07215, P0CX80, P0CX81
    UniProtKB/TrEMBL
    A0A0A1HAP2, A6ZSW1, B3LSH4, C7GV24, C8Z9J0, G2WFC7
    Conserved Domains (1) summary
    pfam11403
    Location:9 → 47
    Yeast_MT; Yeast metallothionein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX80.1
P0CX81.1

Gene LinkOut

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Research Materials