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FSH1 putative serine hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856445, updated on 23-Apr-2026
Official Symbol
FSH1
Official Full Name
putative serine hydrolase
Primary source
SGD:S000001091
Locus tag
YHR049W
See related
AllianceGenome:SGD:S000001091; FungiDB:YHR049W; VEuPathDB:YHR049W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lysophospholipase activity. Involved in apoptotic process. Located in cytoplasm and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See FSH1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (206462..207193)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene arginine/alanine aminopeptidase Neighboring gene Yhk8p Neighboring gene divalent metal ion transporter SMF2 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. Quevillon-Cheruel S, et al. Protein Sci, 2005 May. PMID 15802654, Free PMC Article
  2. FSH1 overexpression triggers apoptosis in Saccharomyces cerevisiae. Gowsalya R, et al. Antonie Van Leeuwenhoek, 2019 Dec. PMID 31363875
  3. FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae. Ramachandran G, et al. Biotechnol Lett, 2021 Jan. PMID 32920715
  4. Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae. Bun JS, et al. PLoS One, 2020. PMID 32182256, Free PMC Article
  5. FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae. Gowsalya R, et al. FEMS Yeast Res, 2019 May 1. PMID 30776074

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on ester bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylcholine lysophospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative serine hydrolase
NP_011915.1
  • Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    206462..207193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179179.1 → NP_011915.1  putative serine hydrolase

    See identical proteins and their annotated locations for NP_011915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKZ7, P38777
    UniProtKB/TrEMBL
    A6ZSV6, B3LSG8, B5VJY0, C7GT88, C8ZAC0, G2WFC2, N1P3B6
    Conserved Domains (1) summary
    pfam03959
    Location:6 → 229
    FSH1; Serine hydrolase (FSH1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38777.1

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