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SRB2 Srb2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856437, updated on 28-Oct-2024

Summary

Official Symbol
SRB2
Official Full Name
Srb2p
Primary source
SGD:S000001083
Locus tag
YHR041C
See related
AllianceGenome:SGD:S000001083; FungiDB:YHR041C; VEuPathDB:YHR041C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRS2; MED20
Summary
Enables TFIID-class transcription factor complex binding activity; protein domain specific binding activity; and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to nutrient levels; and regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See SRB2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (189131..189864, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit G Neighboring gene Bcd1p Neighboring gene NADPH--hemoprotein reductase Neighboring gene 2-deoxyglucose-6-phosphatase

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables TFIID-class transcription factor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein domain specific binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Srb2p
NP_011907.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    189131..189864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179171.1NP_011907.1  TPA: Srb2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKY9, P34162
    UniProtKB/TrEMBL
    B3LSG1, C8ZAB2, N1P568
    Conserved Domains (1) summary
    pfam08612
    Location:1209
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex