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DAP2 dipeptidyl aminopeptidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856423, updated on 18-Sep-2024

Summary

Official Symbol
DAP2
Official Full Name
dipeptidyl aminopeptidase
Primary source
SGD:S000001070
Locus tag
YHR028C
See related
AllianceGenome:SGD:S000001070; FungiDB:YHR028C; VEuPathDB:YHR028C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DPP2
Summary
Enables dipeptidyl-peptidase activity. Predicted to be involved in protein processing. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; asthma; autosomal dominant non-syndromic intellectual disability 33; motor neuron disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See DAP2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (164978..167434, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V0 sector ATPase subunit c'' Neighboring gene proteasome regulatory particle base subunit RPN1 Neighboring gene Yhi9p Neighboring gene mitogen-activated serine/threonine-protein kinase SLT2

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dipeptidyl aminopeptidase
NP_011893.1
  • Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    164978..167434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179158.1NP_011893.1  TPA: dipeptidyl aminopeptidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011893.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKX5, E9P957, P18962
    UniProtKB/TrEMBL
    B3LSE9, C7GTV2, N1P2T7
    Conserved Domains (2) summary
    pfam00326
    Location:608815
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:148508
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region