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VPS29 retromer subunit VPS29 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856403, updated on 18-Sep-2024

Summary

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Official Symbol
VPS29
Official Full Name
retromer subunit VPS29
Primary source
SGD:S000001054
Locus tag
YHR012W
See related
AllianceGenome:SGD:S000001054; FungiDB:YHR012W; VEuPathDB:YHR012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PEP11; VPT6
Summary
Contributes to cargo adaptor activity. Involved in retrograde transport, endosome to Golgi. Located in endosome. Part of retromer, cargo-selective complex. Orthologous to human VPS29 (VPS29 retromer complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VPS29 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (129481..130448)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L27A Neighboring gene putative serine--tRNA ligase DIA4 Neighboring gene peptide alpha-N-acetyltransferase complex A subunit ARD1 Neighboring gene Spo13p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The retromer is co-opted to deliver lipid enzymes for the biogenesis of lipid-enriched tombusviral replication organelles. Feng Z, et al. Proc Natl Acad Sci U S A, 2021 Jan 5. PMID 33376201, Free PMC Article
  2. Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast. Cuesta-Marbán Á, et al. J Biol Chem, 2013 Mar 22. PMID 23335509, Free PMC Article
  3. Evolutionary variations of VPS29, and their implications for the heteropentameric model of retromer. Harbour ME, et al. Commun Integr Biol, 2011 Sep. PMID 22046480, Free PMC Article
  4. Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. Seaman MN, et al. J Cell Biol, 1997 Apr 7. PMID 9105038, Free PMC Article
  5. Expression attenuation as a mechanism of robustness against gene duplication. Ascencio D, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33526669, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to cargo adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to cargo adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of retromer complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of retromer, cargo-selective complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
retromer subunit VPS29
NP_011876.1
  • Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    129481..130448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179142.1 → NP_011876.1  TPA: retromer subunit VPS29 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011876.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV7, P38759
    UniProtKB/TrEMBL
    A6ZSR6, B3LSD3, C8ZA79, G2WF80, N1P1H6
    Conserved Domains (1) summary
    cl13995
    Location:2 → 279
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38759.1

Gene LinkOut

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