VPS29 retromer subunit VPS29 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: VPS29
Gene description: retromer subunit VPS29
Primary source: SGD:S000001054
Locus tag: YHR012W
See related: AllianceGenome:SGD:S000001054
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PEP11; VPT6
Summary: Contributes to cargo adaptor activity. Involved in retrograde transport, endosome to Golgi. Located in endosome. Part of retromer, cargo-selective complex. Orthologous to human VPS29 (VPS29 retromer complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VPS29 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 2

Sequence:: Chromosome: VIII; NC_001140.6 (129481..130448)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the R(98) residue, which is part of a conserved PRLYL motif, is critical for Vps35p binding to Vps26p, while both R(98) and residues 733-944 are needed for efficient binding to Vps29p
Title: Structural features of vps35p involved in interaction with other subunits of the retromer complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the VPS29 gene: The VPS29 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.
Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
contributes_to cargo adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to cargo adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in retrograde transport, endosome to Golgi	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular anatomical entity	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endosome	IPI Inferred from Physical Interaction more info	PubMed
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of retromer complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of retromer complex	IPI Inferred from Physical Interaction more info	PubMed
part_of retromer, cargo-selective complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: retromer subunit VPS29

NP_011876.1

Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

129481..130448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179142.1 → NP_011876.1 TPA: retromer subunit VPS29 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011876.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKV7, P38759

UniProtKB/TrEMBL

A6ZSR6, N1P1H6

Conserved Domains (1) summary

cl13995
Location:2 → 279

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain