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KMO kynurenine 3-monooxygenase [ Homo sapiens (human) ]

Gene ID: 8564, updated on 27-Nov-2024

Summary

Official Symbol
KMOprovided by HGNC
Official Full Name
kynurenine 3-monooxygenaseprovided by HGNC
Primary source
HGNC:HGNC:6381
See related
Ensembl:ENSG00000117009 MIM:603538; AllianceGenome:HGNC:6381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ317G22.1
Summary
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Expression
Broad expression in liver (RPKM 11.5), kidney (RPKM 9.8) and 20 other tissues See more
Orthologs
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Genomic context

See KMO in Genome Data Viewer
Location:
1q43
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (241532378..241595642)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (240943769..241007043)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (241695678..241758944)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904601 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241581573-241582074 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:241602586-241603173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2007 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:241682833-241683429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2828 Neighboring gene fumarate hydratase Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241802798-241803368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241803369-241803938 Neighboring gene opsin 3 Neighboring gene uncharacterized LOC124904603 Neighboring gene CHM like Rab escort protein Neighboring gene WD repeat domain 64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD(P)H oxidase H2O2-forming activity IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kynurenine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kynurenine 3-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kynurenine 3-monooxygenase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitochondrion HTP PubMed 

General protein information

Preferred Names
kynurenine 3-monooxygenase
Names
kynurenine 3-hydroxylase
NP_001397873.1
NP_003670.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410944.1NP_001397873.1  kynurenine 3-monooxygenase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL133390, FO393423
    Consensus CDS
    CCDS91182.1
    Related
    ENSP00000355516.3, ENST00000366558.7
  2. NM_003679.5NP_003670.2  kynurenine 3-monooxygenase isoform 1

    See identical proteins and their annotated locations for NP_003670.2

    Status: REVIEWED

    Source sequence(s)
    AF056032, AI262990, AK291558, AL133390, AU137977, CB989076, DB373228, Y13153
    Consensus CDS
    CCDS1618.1
    UniProtKB/Swiss-Prot
    A2A2U8, A2A2U9, A2A2V0, O15229, Q5SY07, Q5SY08, Q5SY09
    UniProtKB/TrEMBL
    A8K693
    Related
    ENSP00000355517.4, ENST00000366559.9
    Conserved Domains (2) summary
    COG0654
    Location:8361
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:11330
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    241532378..241595642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    240943769..241007043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)