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KMO kynurenine 3-monooxygenase [ Homo sapiens (human) ]

Gene ID: 8564, updated on 7-Oct-2018

Summary

Official Symbol
KMOprovided by HGNC
Official Full Name
kynurenine 3-monooxygenaseprovided by HGNC
Primary source
HGNC:HGNC:6381
See related
Ensembl:ENSG00000117009 MIM:603538; Vega:OTTHUMG00000039635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ317G22.1
Summary
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Expression
Broad expression in liver (RPKM 11.5), kidney (RPKM 9.8) and 20 other tissues See more
Orthologs

Genomic context

See KMO in Genome Data Viewer
Location:
1q43
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (241531883..241595647)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (241695324..241758949)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373230 Neighboring gene fumarate hydratase Neighboring gene uncharacterized LOC105373233 Neighboring gene opsin 3 Neighboring gene CHM like, Rab escort protein 2 Neighboring gene WD repeat domain 64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
kynurenine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kynurenine 3-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
kynurenine 3-monooxygenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 
L-kynurenine metabolic process IEA
Inferred from Electronic Annotation
more info
 
NAD metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
kynurenic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
kynurenine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kynurenine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glutamate secretion, neurotransmission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
response to salt stress IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kynurenine 3-monooxygenase
Names
kynurenine 3-hydroxylase
NP_003670.2
XP_005273394.1
XP_005273395.1
XP_016858138.1
XP_016858139.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003679.4NP_003670.2  kynurenine 3-monooxygenase

    See identical proteins and their annotated locations for NP_003670.2

    Status: REVIEWED

    Source sequence(s)
    AF056032, AI262990, AK291558, AL133390, AU137977, CB989076, DB373228, Y13153
    Consensus CDS
    CCDS1618.1
    UniProtKB/Swiss-Prot
    O15229
    UniProtKB/TrEMBL
    A8K693
    Related
    ENSP00000355517.4, OTTHUMP00000037618, ENST00000366559.8, OTTHUMT00000095612
    Conserved Domains (2) summary
    COG0654
    Location:8361
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:11330
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    241531883..241595647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273338.3XP_005273395.1  kynurenine 3-monooxygenase isoform X2

    Conserved Domains (2) summary
    COG0654
    Location:23280
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:28249
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_017002649.1XP_016858138.1  kynurenine 3-monooxygenase isoform X2

    Conserved Domains (2) summary
    COG0654
    Location:23280
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:28249
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_005273337.1XP_005273394.1  kynurenine 3-monooxygenase isoform X1

    See identical proteins and their annotated locations for XP_005273394.1

    Related
    ENSP00000355516.3, OTTHUMP00000037619, ENST00000366558.7, OTTHUMT00000095613
    Conserved Domains (2) summary
    COG0654
    Location:48418
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:51370
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_017002650.1XP_016858139.1  kynurenine 3-monooxygenase isoform X2

    Conserved Domains (2) summary
    COG0654
    Location:23280
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:28249
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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