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SOD2 superoxide dismutase SOD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856399, updated on 21-Nov-2024

Summary

Official Symbol
SOD2
Official Full Name
superoxide dismutase SOD2
Primary source
SGD:S000001050
Locus tag
YHR008C
See related
AllianceGenome:SGD:S000001050; FungiDB:YHR008C; VEuPathDB:YHR008C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables superoxide dismutase activity. Involved in reactive oxygen species metabolic process. Located in mitochondrial matrix. Used to study Alzheimer's disease; Parkinson's disease; and cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See SOD2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (122889..123590, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene sterol 14-demethylase Neighboring gene uncharacterized protein Neighboring gene Tda3p Neighboring gene ribosomal 60S subunit protein L27A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
superoxide dismutase SOD2
NP_011872.1
  • Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    122889..123590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179138.1NP_011872.1  TPA: superoxide dismutase SOD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011872.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV3, P00447
    UniProtKB/TrEMBL
    A6ZSR2, B3LSC9, B5VJT4, C7GMQ3, C8ZA75, G2WF76, N1P9K8, S4VPL7
    Conserved Domains (1) summary
    COG0605
    Location:25233
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]