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LEU5 coenzyme A transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 856391, updated on 8-Feb-2025

Summary

Official Symbol
LEU5
Official Full Name
coenzyme A transporter
Primary source
SGD:S000001044
Locus tag
YHR002W
See related
AllianceGenome:SGD:S000001044; FungiDB:YHR002W; VEuPathDB:YHR002W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables coenzyme A transmembrane transporter activity. Involved in coenzyme A transport. Located in mitochondrial inner membrane. Used to study Graves' disease. Orthologous to human SLC25A16 (solute carrier family 25 member 16). [provided by Alliance of Genome Resources, Feb 2025]
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Genomic context

See LEU5 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (108812..109885)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein related protein OSH7 Neighboring gene ubiquinol--cytochrome-c reductase subunit 10 Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene Nem1-Spo7 phosphatase catalytic subunit NEM1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables coenzyme A transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables coenzyme A transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in coenzyme A transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial coenzyme A transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coenzyme A transporter
NP_011865.1
  • Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    108812..109885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179132.1NP_011865.1  TPA: coenzyme A transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKR9, P38702
    UniProtKB/TrEMBL
    A6ZSQ4, B3LSC0, C7GMR1, C8ZA68, G2WF68, N1P519
    Conserved Domains (2) summary
    PTZ00169
    Location:38329
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:32127
    Mito_carr; Mitochondrial carrier protein