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QCR2 ubiquinol--cytochrome-c reductase subunit 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856321, updated on 12-Jan-2022

Summary

Gene symbol
QCR2
Gene description
ubiquinol--cytochrome-c reductase subunit 2
Primary source
SGD:S000006395
Locus tag
YPR191W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COR2; UCR2
Summary
Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial crista. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See QCR2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (919381..920487)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene SKI complex subunit tetratricopeptide repeat protein SKI3 Neighboring gene DNA-directed RNA polymerase III subunit C82 Neighboring gene Aqy1p Neighboring gene histone acetyltransferase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the QCR2 gene: The QCR2 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ubiquinol-cytochrome-c reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquinol--cytochrome-c reductase subunit 2
NP_015517.1
  • Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    919381..920487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184288.1NP_015517.1  TPA: ubiquinol--cytochrome-c reductase subunit 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015517.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07257
    Conserved Domains (2) summary
    COG0612
    Location:1362
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:17163
    Peptidase_M16; Insulinase (Peptidase family M16)
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