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THOC5 THO complex 5 [ Homo sapiens (human) ]

Gene ID: 8563, updated on 5-Jul-2020

Summary

Official Symbol
THOC5provided by HGNC
Official Full Name
THO complex 5provided by HGNC
Primary source
HGNC:HGNC:19074
See related
Ensembl:ENSG00000100296 MIM:612733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fmip; PK1.3; fSAP79; C22orf19
Expression
Ubiquitous expression in testis (RPKM 10.3), endometrium (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See THOC5 in Genome Data Viewer
Location:
22q12.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (29505879..29553760, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29904156..29949749, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985541 Neighboring gene neurofilament heavy Neighboring gene nipsnap homolog 1 Neighboring gene Sharpr-MPRA regulatory region 2653 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 4 Neighboring gene neurofibromin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
NHGRI GWA Catalog
THOC5: a novel gene involved in HDL-cholesterol metabolism.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of DNA-templated transcription, elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
primitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THO complex subunit 5 homolog
Names
Fms-interacting protein
NF2/meningioma region protein pK1.3
PP39.2
functional spliceosome-associated protein 79
hTREX90
placental protein 39.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002877.2NP_001002877.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002877.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, AC005529, BQ184247, BX381026, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    Q13769
    UniProtKB/TrEMBL
    A0A024R1D6
    Related
    ENSP00000380971.2, ENST00000397873.6
    Conserved Domains (1) summary
    pfam09766
    Location:97452
    FimP; Fms-interacting protein
  2. NM_001002878.1NP_001002878.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BX400943, BX404329, CN387648, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    Q13769
    UniProtKB/TrEMBL
    A0A024R1D6
    Related
    ENSP00000380970.1, ENST00000397872.5
    Conserved Domains (1) summary
    pfam09766
    Location:97452
    FimP; Fms-interacting protein
  3. NM_001002879.1NP_001002879.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BU187531, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    Q13769
    UniProtKB/TrEMBL
    A0A024R1D6
    Related
    ENSP00000380969.1, ENST00000397871.5
    Conserved Domains (1) summary
    pfam09766
    Location:97452
    FimP; Fms-interacting protein
  4. NM_003678.5NP_003669.4  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_003669.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, AC005529, BQ184247, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    Q13769
    UniProtKB/TrEMBL
    A0A024R1D6
    Related
    ENSP00000420306.1, ENST00000490103.5
    Conserved Domains (1) summary
    pfam09766
    Location:97452
    FimP; Fms-interacting protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    29505879..29553760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261797.1XP_005261854.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_005261854.1

    Conserved Domains (1) summary
    pfam09766
    Location:97463
    FimP; Fms-interacting protein
  2. XM_005261798.1XP_005261855.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_005261855.1

    Conserved Domains (1) summary
    pfam09766
    Location:97463
    FimP; Fms-interacting protein
  3. XM_024452296.1XP_024308064.1  THO complex subunit 5 homolog isoform X2

    Conserved Domains (1) summary
    pfam09766
    Location:97452
    FimP; Fms-interacting protein
  4. XM_017029027.2XP_016884516.1  THO complex subunit 5 homolog isoform X1

    Conserved Domains (1) summary
    pfam09766
    Location:97463
    FimP; Fms-interacting protein
  5. XM_005261801.4XP_005261858.1  THO complex subunit 5 homolog isoform X3

    Conserved Domains (1) summary
    pfam09766
    Location:1113
    FimP; Fms-interacting protein
  6. XM_005261799.1XP_005261856.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_005261856.1

    Conserved Domains (1) summary
    pfam09766
    Location:97463
    FimP; Fms-interacting protein
  7. XM_006724347.1XP_006724410.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_006724410.1

    Conserved Domains (1) summary
    pfam09766
    Location:97463
    FimP; Fms-interacting protein

RNA

  1. XR_001755346.1 RNA Sequence

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