ORC4 origin recognition complex subunit 4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ORC4
Gene description: origin recognition complex subunit 4
Primary source: SGD:S000006366
Locus tag: YPR162C
Gene type: protein coding
RNA name: origin recognition complex subunit 4
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

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See ORC4 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (866715..868304, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Since the site of one of the missense mutations in the human ORC4 alleles is conserved between humans and yeast, we sought to determine in what way this single amino acid change affects the process of chromosome replication, by introducing the comparable mutation into yeast (orc4Y232C).
Title: Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast.
interaction is mediated by the C-terminal region of Orc4p, and the N-terminal region of Orc5p
Title: Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Activation of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Assembly of the ORC complex at the origin of replication, organism-specific biosystem (from REACTOME)
Assembly of the ORC complex at the origin of replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Assembly of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Association of licensing factors with the pre-replicative complex, organism-specific biosystem (from REACTOME)
Association of licensing factors with the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle - yeast, organism-specific biosystem (from KEGG)
Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
Cell cycle - yeast, conserved biosystem (from KEGG)
Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
DNA Replication Pre-Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
M/G1 Transition, organism-specific biosystem (from REACTOME)
M/G1 Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Meiosis - yeast, organism-specific biosystem (from KEGG)
Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Meiosis - yeast, conserved biosystem (from KEGG)
Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Origin recognition complex, organism-specific biosystem (from KEGG)
Origin recognition complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
Origin recognition complex, conserved biosystem (from KEGG)
Origin recognition complex, conserved biosystemStructural complex; Genetic information processing; Replication system
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the ORC4 gene: The ORC4 gene is conserved in Rhesus monkey, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, and N.crassa.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
chromatin silencing at silent mating-type cassette	IDA Inferred from Direct Assay more info	PubMed
pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
DNA replication preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
nuclear origin of replication recognition complex	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
origin recognition complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: origin recognition complex subunit 4

NP_015488.1

Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

866715..868304 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184259.1 → NP_015488.1 TPA: origin recognition complex subunit 4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015488.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54791

Conserved Domains (2) summary

COG1474
Location:95 → 276

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam14629
Location:286 → 517

ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus