KRE6 beta-glucan synthesis-associated protein KRE6 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: KRE6
Official Full Name: beta-glucan synthesis-associated protein KRE6
Primary source: SGD:S000006363
Locus tag: YPR159W
See related: AllianceGenome:SGD:S000006363; FungiDB:YPR159W; VEuPathDB:YPR159W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CWH48
Summary: Enables glucosidase activity. Involved in (1->6)-beta-D-glucan biosynthetic process and fungal-type cell wall organization. Located in several cellular components, including endoplasmic reticulum membrane; site of polarized growth; and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.
Title: Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.
the action of multiple ER chaperon-like proteins is required for proper folding and localization of Kre6 and probably Skn1 to function in beta-1,6-glucan synthesis.
Title: Action of multiple endoplasmic reticulum chaperon-like proteins is required for proper folding and polarized localization of Kre6 protein essential in yeast cell wall β-1,6-glucan synthesis.
This is the first evidence of a beta-1,6-glucan-related protein, Kre6, showing the polarized membrane localization that correlates with its biological function
Title: Kre6 protein essential for yeast cell wall beta-1,6-glucan synthesis accumulates at sites of polarized growth.
Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae.
Title: KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucosidase activity	IEA Inferred from Electronic Annotation more info
enables glucosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in (1->6)-beta-D-glucan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in (1->6)-beta-D-glucan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in (1->6)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	HDA more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IDA Inferred from Direct Assay more info	PubMed

NP_015485.1

Glucosyl hydrolase required for beta-1,6-glucan biosynthesis; type II integral membrane protein that localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication