SUA7 transcription factor TFIIB [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SUA7
Gene description: transcription factor TFIIB
Primary source: SGD:S000006290
Locus tag: YPR086W
Gene type: protein coding
RNA name: transcription factor TFIIB
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SOH4

Genomic context

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See SUA7 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (710101..711138)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Studies indicate that the covalent, flexible linker ensured that transcription factor TFIIB (TFIIB) was recruited stoichiometrically near its binding site on the RNA polymerase (Pol) II (Pol II) surface.
Title: Structure determination of transient transcription complexes.
TFIIB interaction with the CF1 complex and Pap1 is crucial for gene looping and transcriptional regulation.
Title: Evidence for a complex of transcription factor IIB with poly(A) polymerase and cleavage factor 1 subunits required for gene looping.
crystal structure of RNA polymerase II-TFIIB complex at 3.8 A resolution revealing carboxyl-terminal region of TFIIB, located above polymerase active center cleft but showing none of B finger; linker between amino- & carboxyl-terminal regions also seen
Title: Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.
the crystal structure of the complete RNA polymerase II - transcription factor IIB complex at 4.3 A resolution
Title: RNA polymerase II-TFIIB structure and mechanism of transcription initiation.
TFIIB binds RNA Polymerase II at the terminator, which in turn associates with the promoter scaffold giving TFIIB a role in gene looping.
Title: A transcription-independent role for TFIIB in gene looping.
TBP1(E186D) temperature-sensitivity and slow-growth phenotypes might have been caused by insufficient amounts of Tbp1p for efficient transcription of the rRNA genes by RNA polymerase I
Title: TFIIB/SUA7(E202G) is an allele-specific suppressor of TBP1(E186D).
Results describe the architecture of transcription factor IIB and the the RNA polymerase II transcription preinitiation complex (PIC).
Title: Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC.
TFIIB nuclear import is mediated by Kap114p
Title: Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo-binding domains.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the SUA7 gene: The SUA7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II complex binding	IPI Inferred from Physical Interaction more info	PubMed
RNA polymerase II complex recruiting activity	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II complex recruiting activity	IMP Inferred from Mutant Phenotype more info	PubMed
TBP-class protein binding	IDA Inferred from Direct Assay more info	PubMed
TBP-class protein binding	IEA Inferred from Electronic Annotation more info
TBP-class protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
RNA polymerase II preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-templated	IEA Inferred from Electronic Annotation more info
transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
transcriptional open complex formation at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
transcriptional preinitiation complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor TFIIB

NP_015411.1

Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

710101..711138

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184183.1 → NP_015411.1 TPA: transcription factor TFIIB [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015411.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29055

Conserved Domains (1) summary

COG1405
Location:21 → 333

SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]