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TKL1 transketolase TKL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856188, updated on 4-Dec-2018

Summary

Gene symbol
TKL1
Gene description
transketolase TKL1
Primary source
SGD:S000006278
Locus tag
YPR074C
Gene type
protein coding
RNA name
transketolase TKL1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See TKL1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (692796..694838, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit NOT5 Neighboring gene tyrosine protein phosphatase LTP1 Neighboring gene Opy2p Neighboring gene hypothetical protein

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TKL1 gene: The TKL1 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.

Gene Ontology Provided by GO

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transketolase activity IEA
Inferred from Electronic Annotation
more info
 
transketolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transketolase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
pentose-phosphate shunt IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transketolase TKL1
NP_015399.1
  • Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    692796..694838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184171.1NP_015399.1  TPA: transketolase TKL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015399.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P23254
    Conserved Domains (1) summary
    TIGR00232
    Location:9664
    tktlase_bact; transketolase, bacterial and yeast
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