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FCY1 cytosine deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856175, updated on 5-Jul-2025
Official Symbol
FCY1
Official Full Name
cytosine deaminase
Primary source
SGD:S000006266
Locus tag
YPR062W
See related
AllianceGenome:SGD:S000006266; FungiDB:YPR062W; VEuPathDB:YPR062W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cytosine deaminase activity. Involved in cytidine metabolic process; cytosine metabolic process; and pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See FCY1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (677165..677641)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene chorismate mutase ARO7 Neighboring gene Jid1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Hydrogen-bond detection, configuration assignment and rotamer correction of side-chain amides in large proteins by NMR spectroscopy through protium/deuterium isotope effects. Liu A, et al. Chembiochem, 2008 Nov 24. PMID 18973166, Free PMC Article
  2. Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugates. Senter PD, et al. Bioconjug Chem, 1991 Nov-Dec. PMID 1805942
  3. Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Erbs P, et al. Curr Genet, 1997 Jan. PMID 9000374
  4. Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. Hamstra DA, et al. Hum Gene Ther, 1999 Aug 10. PMID 10466633
  5. Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts. Kievit E, et al. Cancer Res, 2000 Dec 1. PMID 11118048

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cytosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytosine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in cytidine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytidine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytosine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cytosine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine-containing compound salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine-containing compound salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cytosine deaminase
NP_015387.1
  • Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    677165..677641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184159.1 → NP_015387.1  TPA: cytosine deaminase

    See identical proteins and their annotated locations for NP_015387.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W467, Q12178
    UniProtKB/TrEMBL
    A6ZWV0, B3LLB6, C7GY48, C8ZJ87, G2WPN5, N1P257
    Conserved Domains (1) summary
    COG0590
    Location:6 → 147
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12178.1

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