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YMC1 organic acid transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 856171, updated on 12-Aug-2025
Official Symbol
YMC1
Official Full Name
organic acid transporter
Primary source
SGD:S000006262
Locus tag
YPR058W
See related
AllianceGenome:SGD:S000006262; FungiDB:YPR058W; VEuPathDB:YPR058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glycine transmembrane transporter activity. Involved in glycine import into mitochondrion and heme biosynthetic process. Located in mitochondrion. Orthologous to several human genes including SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See YMC1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (673751..674674)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene TFIIH/NER complex subunit TFB4 Neighboring gene Brr1p Neighboring gene chorismate mutase ARO7 Neighboring gene Jid1p

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. YMC1, a yeast gene encoding a new putative mitochondrial carrier protein. Graf R, et al. Yeast, 1993 Mar. PMID 8488731
  2. Mitochondrial transporters involved in oleic acid utilization and glutamate metabolism in yeast. Trotter PJ, et al. Arch Biochem Biophys, 2005 Oct 1. PMID 16140254
  3. Sym1, the yeast ortholog of the MPV17 human disease protein, is a stress-induced bioenergetic and morphogenetic mitochondrial modulator. Dallabona C, et al. Hum Mol Genet, 2010 Mar 15. PMID 20042463
  4. The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins. Laborenz J, et al. Mol Biol Cell, 2021 Apr 15. PMID 33596095, Free PMC Article
  5. Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. el Moualij B, et al. Yeast, 1997 May. PMID 9178508

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables organic acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables organic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycine import into mitochondrion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heme biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
organic acid transporter
NP_015383.1
  • Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    673751..674674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184155.1 → NP_015383.1  TPA: organic acid transporter

    See identical proteins and their annotated locations for NP_015383.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W464, P32331, Q12002
    UniProtKB/TrEMBL
    A0A0L8VGU9, A6ZWU7, B3LLB3, C7GY45, C8ZJ83, G2WPN2, N1NXK4
    Conserved Domains (1) summary
    pfam00153
    Location:215 → 307
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32331.2

Gene LinkOut

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