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BRR1 Brr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856170, updated on 12-Aug-2025
Official Symbol
BRR1
Official Full Name
Brr1p
Primary source
SGD:S000006261
Locus tag
YPR057W
See related
AllianceGenome:SGD:S000006261; FungiDB:YPR057W; VEuPathDB:YPR057W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables snRNA binding activity. Involved in spliceosomal complex assembly. Part of small nuclear ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See BRR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (672471..673496)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene exocyst subunit SEC8 Neighboring gene TFIIH/NER complex subunit TFB4 Neighboring gene organic acid transporter Neighboring gene chorismate mutase ARO7

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. Noble SM, et al. EMBO J, 1996 Aug 15. PMID 8861964, Free PMC Article
  2. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Noble SM, et al. Genetics, 1996 May. PMID 8722763, Free PMC Article
  3. Mutations in the Saccharomyces cerevisiae kinase Cbk1p lead to a fertility defect that can be suppressed by the absence of Brr1p or Mpt5p (Puf5p), proteins involved in RNA metabolism. Bourens M, et al. Genetics, 2009 Sep. PMID 19546315, Free PMC Article
  4. Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors. Schwer B, et al. Nucleic Acids Res, 2013 Aug. PMID 23754852, Free PMC Article
  5. Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. Qiu ZR, et al. RNA, 2012 Nov. PMID 23002122, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2.
    Title: Will the circle be unbroken: specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of Gemin2.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small nuclear ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small nuclear ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Brr1p
NP_015382.1
  • snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    672471..673496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184154.1 → NP_015382.1  TPA: Brr1p

    See identical proteins and their annotated locations for NP_015382.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W463, Q99177
    UniProtKB/TrEMBL
    A0A0L8VG39, B3LLB2, B5VTK9, C7GY44, C8ZJ82, N1NWC0
    Conserved Domains (1) summary
    pfam04938
    Location:141 → 337
    SIP1; Survival motor neuron (SMN) interacting protein 1 (SIP1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99177.1

Gene LinkOut

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