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MAK3 peptide alpha-N-acetyltransferase MAK3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856163, updated on 18-Jan-2023

Summary

Gene symbol
MAK3
Gene description
peptide alpha-N-acetyltransferase MAK3
Primary source
SGD:S000006255
Locus tag
YPR051W
See related
AllianceGenome:SGD:S000006255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NAA30
Summary
Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and regulation of protein localization. Part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MAK3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (664960..665490)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene NAPDH-dependent diflavin reductase Neighboring gene autophagy protein ATG11 Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene mitogen-activated protein kinase SMK1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide alpha-N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in N-terminal protein amino acid acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NatC complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptide alpha-N-acetyltransferase MAK3
NP_015376.1
  • Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    664960..665490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184148.1NP_015376.1  TPA: peptide alpha-N-acetyltransferase MAK3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015376.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W458, Q03503
    UniProtKB/TrEMBL
    A0A8H4BUX1, N1P245
    Conserved Domains (1) summary
    COG0456
    Location:26162
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]