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TIF5 translation initiation factor eIF5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856154, updated on 4-Aug-2021

Summary

Gene symbol
TIF5
Gene description
translation initiation factor eIF5
Primary source
SGD:S000006245
Locus tag
YPR041W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SUI5
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Genomic context

See TIF5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (648704..649921)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene flavin-linked sulfhydryl oxidase Neighboring gene Irc16p Neighboring gene Tip41p Neighboring gene Puf2p Neighboring gene ribosomal 60S subunit protein L43A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TIF5 gene: The TIF5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP-dissociation inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
enables translation initiation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic 48S preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of multi-eIF complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translation initiation factor eIF5
NP_015366.1
  • Translation initiation factor eIF5; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-2, as part of the 43S preinitiation complex, and as a GDP dissociation inhibitor (GDI) to prevent recycling of eIF2; human ortholog eIF5 complements the yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    648704..649921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184138.1NP_015366.1  TPA: translation initiation factor eIF5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015366.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38431
    Conserved Domains (2) summary
    cd11561
    Location:242392
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:8127
    eIF-5_eIF-2B; Domain found in IF2B/IF5
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