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GLN1 glutamate--ammonia ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856147, updated on 5-Sep-2021

Summary

Gene symbol
GLN1
Gene description
glutamate--ammonia ligase
Primary source
SGD:S000006239
Locus tag
YPR035W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See GLN1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (642208..643320)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histidine--tRNA ligase Neighboring gene Arp7p Neighboring gene H(+)-transporting V1 sector ATPase subunit H Neighboring gene Spo24p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the GLN1 gene: The GLN1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate-ammonia ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate-ammonia ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate-ammonia ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate-ammonia ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
glutamate--ammonia ligase
NP_015360.2
  • Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    642208..643320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184132.2NP_015360.2  TPA: glutamate--ammonia ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015360.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32288
    Conserved Domains (1) summary
    PLN02284
    Location:19352
    PLN02284; glutamine synthetase
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