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HTS1 histidine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856145, updated on 18-Jan-2023

Summary

Gene symbol
HTS1
Gene description
histidine--tRNA ligase
Primary source
SGD:S000006237
Locus tag
YPR033C
See related
AllianceGenome:SGD:S000006237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TS4572; TSM4572
Summary
Enables aminoacyl-tRNA ligase activity. Involved in histidyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Used to study Charcot-Marie-Tooth disease, axonal type 2W. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to several human genes including HARS1 (histidyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HTS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (637379..639019, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nto1p Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene Arp7p Neighboring gene glutamate--ammonia ligase

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the HTS1 gene: The HTS1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
 
enables histidine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histidine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histidyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histidyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histidyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in histidyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
histidine--tRNA ligase
NP_015358.1
  • Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    637379..639019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184130.1NP_015358.1  TPA: histidine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07263, Q12095
    UniProtKB/TrEMBL
    A0A0L8VGA6, A0A6C1E1Z1, A0A8H4BU25, B5VTJ1, C7GQA5, C8ZJ57, N1NW10
    Conserved Domains (1) summary
    PLN02972
    Location:56503
    PLN02972; Histidyl-tRNA synthetase