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NCR1 sphingolipid transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 856101, updated on 10-Feb-2026
Official Symbol
NCR1
Official Full Name
sphingolipid transporter
Primary source
SGD:S000005927
Locus tag
YPL006W
See related
AllianceGenome:SGD:S000005927; FungiDB:YPL006W; VEuPathDB:YPL006W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sterol binding activity. Involved in sphingolipid metabolic process and sterol transport. Located in fungal-type vacuole membrane. Used to study Niemann-Pick disease and Niemann-Pick disease type C1. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C1. Orthologous to several human genes including NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See NCR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (544631..548143)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene DNA helicase Neighboring gene transcription factor TFIIIC subunit TFC8 Neighboring gene Aep3p Neighboring gene lipid-binding protein LSP1

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. Malathi K, et al. J Cell Biol, 2004 Feb 16. PMID 14970192, Free PMC Article
  2. Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein. Nel L, et al. Life Sci Alliance, 2025 Jan. PMID 39455279, Free PMC Article
  3. An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. Munkacsi AB, et al. J Biol Chem, 2011 Jul 8. PMID 21489983, Free PMC Article
  4. Iron Limitation Restores Autophagy and Increases Lifespan in the Yeast Model of Niemann-Pick Type C1. Martins TS, et al. Int J Mol Sci, 2023 Mar 25. PMID 37047194, Free PMC Article
  5. Genomic modifiers of neurological resilience in a Niemann-Pick C family. Las Heras M, et al. FEBS Lett, 2025 Sep. PMID 40504793

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein.
    Title: Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein.
  2. this study presents four structures of yeast NCR1 and NPC2.
    Title: Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
  3. These data show that Ncr1p and Npc2p proteins promote microautophagy in stationary phase and under nitrogen starvation conditions, likely by increasing sterol in the limiting membrane of the vacuole.
    Title: Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole.
  4. Authors show that yeast cells lacking Ncr1p, an orthologue of mammalian NPC1, exhibited a higher sensitivity to hydrogen peroxide and a shortened chronological lifespan.
    Title: Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.
  5. Results identify the first phenotype caused by deletion of NCR1 from the yeast genome, resistance to the ether lipid drug, edelfosine.
    Title: A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sphingolipid transporter
NP_015319.1
  • Vacuolar membrane protein involved in sterol trafficking with Npc2p; conformational changes drive sterol translocation across the glycocalyx and into the vacuolar membrane; involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCBs), similar to accumulation of lipids observed in patients with Neimann-Pick C disease due to loss-of-function mutations in human NPC1; transits through the vacuolar protein sorting pathway via the AP-3 pathway

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    544631..548143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183820.1 → NP_015319.1  sphingolipid transporter

    See identical proteins and their annotated locations for NP_015319.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W406, Q12200
    UniProtKB/TrEMBL
    B3LL56, C8ZJ20, N1NVZ9
    Conserved Domains (1) summary
    TIGR00917
    Location:23 → 1140
    2A060601; Niemann-Pick C type protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12200.1

Gene LinkOut

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