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CHL1 Chl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856099, updated on 27-Oct-2018

Summary

Gene symbol
CHL1
Gene description
Chl1p
Primary source
SGD:S000005929
Locus tag
YPL008W
Gene type
protein coding
RNA name
Chl1p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CTF1; LPA9; MCM12

Genomic context

See CHL1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (539385..541970)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene coatomer subunit zeta Neighboring gene Rqc2p Neighboring gene transcription factor TFIIIC subunit TFC8 Neighboring gene sphingolipid transporter

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CHL1 gene: The CHL1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP-dependent DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
establishment of sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
interstrand cross-link repair IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid cohesion IPI
Inferred from Physical Interaction
more info
PubMed 
nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Chl1p
NP_015317.1
  • Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    539385..541970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183822.1NP_015317.1  TPA: Chl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015317.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22516
    Conserved Domains (4) summary
    smart00488
    Location:8438
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:136849
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:651835
    Helicase_C_2; Helicase C-terminal domain
    cl19107
    Location:415507
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
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